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The tachycardia and rise in myocardial contractile power viewed in intact animals does not appear in isolated hearts (Langendorff) in a concentration of 0.1 mg of ketamine hydrochloride or in Starling dog coronary heart-lung preparations in a ketamine hydrochloride focus of fifty mg/kg of HLP. These observations assist the hypothesis that the hypertension produced by ketamine hydrochloride is due to selective activation of central cardiac stimulating mechanisms leading to an increase in cardiac output. The Doggy myocardium isn't sensitized to epinephrine and ketamine hydrochloride appears to have a weak antiarrhythmic action.

Since pharyngeal and laryngeal reflexes are usually Energetic, ketamine hydrochloride really should not be made use of by itself in surgery or diagnostic procedures of the pharynx, larynx, or bronchial tree.

CONTRAINDICATIONS In sufferers for whom a substantial elevation of hypertension could be a serious hazard (four).

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Though antidepressants function for some, numerous Other people discover no aid. Examine to find out about the therapeutic employs of ketamine for depression.

Ketamine is indicated being an anesthetic agent for advisable diagnostic and surgical strategies. If skeletal muscle leisure is needed, it ought to be coupled with a muscle relaxant.